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[Inhibition effect of IL-1beta on calcium channels currents in cultured cortical neurons of rat].
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhou, Chen |
| Copyright Year | 2010 |
| Abstract | Interleukin-1beta (IL-1beta) is an important proinflammatory cytokine that exert wide biological functions in the central nervous system (CNS). Voltage-gated Ca2+ channels in plasma membrane are essential components of Ca2+ signal whose change on pathological conditions is closely related to processes of diseases. Although both IL-1beta and Ca2+ channels have key roles in injury and disease of the brain, so far their relations have been reported in few studies. The effects of IL-1beta on Ca2+ channels in cultured cortical neurons of rats were investigated using patch-clamp recording in present research. Our results showed that both 10 and 50 ng/mL of IL-1beta treatment inhibit the Ca2+ currents in time and dose dependent manner, without the change of activation properties of voltage-gated Ca2+ channels (VGCC)s. |
| Starting Page | 89 |
| Ending Page | 93 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 20446459 |
| Journal | Medline |
| Volume Number | 31 |
| Issue Number | 1 |
| Alternate Webpage(s) | https://tspace.library.utoronto.ca/bitstream/1807/64457/1/zr10013.pdf |
| Journal | Dong wu xue yan jiu = Zoological research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
