NDLI: An Interview with Michel Sadelain, MD, PhD.

Please wait, while we are loading the content...

An Interview with Michel Sadelain, MD, PhD.

Content Provider	Semantic Scholar
Author	Adair, Jennifer E.
Copyright Year	2018
Abstract	MS: 2017 is indeed a banner year for cell and gene therapies with the first approvals of CAR therapies, and likely many more to follow. This is the fruit of decades of preclinical research on T-cell engineering. For me, this endeavor started about 30 years ago, when I was a PhD student in immunology after having previously obtained a medical degree. It was at the time becoming clear that the immune system could, on occasion, eliminate tumors. Oncologists had already observed rare, seemingly spontaneous tumor regressions occurring in association with autoimmunity; bonemarrow transplanters were coming to realize that much of the benefit of their transplants was due not to chemotherapy but to T cell–mediated graftversus-tumor responses. The latter was an accidental discovery of the potency of adoptive cell therapy insofar that the motivation for the transplant had been the need for hematopoietic rescue following intensive chemotherapy. The increased relapses that occurred when T cells were removed from the graft (to prevent graftversus-host disease) made it clear that it was the T cells that eliminated residual tumor and prevented relapse. Michel Sadelain, MD, PhD Director for the Center for Cell Engineering Memorial Sloan-Kettering Cancer Center
Starting Page	530
Ending Page	533
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1089/hum.2018.29063.msa
Alternate Webpage(s)	https://www.mskcc.org/sites/default/files/node/4391/documents/hum.2018.29063.pdf
PubMed reference number	29715074
Alternate Webpage(s)	https://doi.org/10.1089/hum.2018.29063.msa
Journal	Medline
Volume Number	29
Issue Number	5
Journal	Human gene therapy
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Biography

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

An Interview with Judd Marmor, MD

An Interview With Peter Greenwald, MD, PhD.

Obituary: Ersan Odaci, MD, PhD

Early clinical xenotransplantation experiences-An interview with Thomas E. Starzl, MD, PhD.

30 Years Later-Reflections on Human Gene Therapy: An Interview with Terry Flotte, MD.

An Interview With Peter Greenwald, MD, PhD

Prof Ismet Ceric, MD, PhD (1935-2017)

Prof Amela Kulenovic, MD, PhD (1956-2018)

A tribute to Richard F. Edlich, MD, PhD.

An Interview with Michel Sadelain, MD, PhD.

Similar Documents

An Interview with Judd Marmor, MD

An Interview With Peter Greenwald, MD, PhD.

Obituary: Ersan Odaci, MD, PhD

Early clinical xenotransplantation experiences-An interview with Thomas E. Starzl, MD, PhD.

30 Years Later-Reflections on Human Gene Therapy: An Interview with Terry Flotte, MD.

An Interview With Peter Greenwald, MD, PhD

Prof Ismet Ceric, MD, PhD (1935-2017)

Prof Amela Kulenovic, MD, PhD (1956-2018)

A tribute to Richard F. Edlich, MD, PhD.

An Interview with Michel Sadelain, MD, PhD.