Loading...
Please wait, while we are loading the content...
Allergy to fish parvalbumins: studies on the cross-reactivity of allergens from 9 commonly consumed fish.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Do, Thien Van Elsayed, Said Florvaag, Erik Hordvik, Ivar Endresen, Curt |
| Copyright Year | 2005 |
| Abstract | BACKGROUND Fish-hypersensitive patients can probably tolerate some fish species while being allergic to others. OBJECTIVE To determine the allergenic cross-reactivity between 9 commonly edible fish: cod, salmon, pollack, mackerel, tuna, herring, wolffish, halibut, and flounder. METHODS Sera from 10 patients allergic to fish and rabbit antisera against 3 parvalbumins (Gad c 1, Sal s 1, and The c 1) were used. Cross-reactivity was investigated by SDS/PAGE and IgE immunoblotting, IgG ELISA, IgE ELISA inhibition, and skin prick test (SPT). RESULTS Cod (Gad c 1), salmon (Sal s 1), pollack (The c 1), herring, and wolffish share antigenic and allergenic determinants as shown by immunoblots and IgE ELISA, whereas halibut, flounder, tuna, and mackerel displayed lowest cross-reactivities. The highest mean IgE ELISA inhibition percent of 10 sera was obtained by Gad c 1, followed by The c 1, herring, Sal s 1, wolffish, halibut, flounder, tuna, and mackerel with the least inhibition. Nine of the 10 patients showed positive SPT to cod, salmon, and pollack; 8 patients reacted to recombinant (r) Sal s 1. Positive SPTs to rGad c 1 and rThe c 1 were demonstrated in 1 patient. CONCLUSION Gad c 1, Sal s 1, The c 1, herring, and wolffish contained the most potent cross-reacting allergens, whereas halibut, flounder, tuna, and mackerel were the least allergenic in the current study. The latter could probably be tolerated by some of the tested patients. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.jaci.2005.07.033 |
| PubMed reference number | 16337465 |
| Journal | Medline |
| Volume Number | 116 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://docshare04.docshare.tips/files/18814/188146541.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.jaci.2005.07.033 |
| Journal | The Journal of allergy and clinical immunology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
