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Stability Indicating RP- High-Performance Liquid Chromatography Determination of Tegaserod Maleate in bulk and solid dosage formulations
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kr, Venugopala Reddy Naik, Arthob Keshavayya, Jathi |
| Copyright Year | 2012 |
| Abstract | A simple, fast, precise and accurate rapid reverse phase high-performance liquid chromatography (HPLC) method was developed for the quantitative determination of tegaserod maleate in bulk & solid dosage formulations. The drug was chromatographed on (SUPLEX PKB-100) column. Eluents were monitored at a wavelength 277 nm using a mixture of acetonitrile and 0.05 M potassium phosphate buffer pH 3.0, consisting of 0.005 M 1-Octanesulphonic acid sodium salt, methanol in the ratio of 50:22:28. A linear response (r = 0.9999) was observed in the range of 25g/ml-75gmL -1 . The proposed method is sufficiently selective to distinguish the parent drug and the degradation products after hydrolysis, photolysis, or chemical oxidation and from excipients .The method showed good recoveries (average 99.45%) and the relative standard deviation 1.0%. The developed method can be used for routine quality control analysis of tegaserod maleate in solid dosage as well as bulk formulations. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://shodhganga.inflibnet.ac.in:8080/jspui/bitstream/10603/86457/10/10_chapter%203.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
