Intelligent Drug Delivery System Based on Mesoporous Silica Nanoparticles Coated with an Ultra-pH-Sensitive Gatekeeper and Poly(ethylene glycol)

Content Provider	Semantic Scholar
Author	Chen, Tianchan Xiao, H. Z. Chen, Yanxiao Chen, Min Li, Jianshu
Copyright Year	2016
Abstract	Mesoporous silica nanoparticles (MSNs) exhibit significant advantages for efficient drug/gene delivery but it is hard for simple MSNs to deliver the loaded drug to the target sites of disease. Considering that there are some well-known pH differences in the body, it is a useful strategy to modify the exterior surface of MSNs with stimuli-responsive gatekeepers to realize open–close transformation of their mesopores. In this work, multifunctional pH-sensitive MSNs were designed with mixed polymeric coatings, that is, poly(ethylene glycol) (PEG) as a dispersity-enhancer and poly(2-(pentamethyleneimino)ethyl methacrylate) (PPEMA) as an ultra-pH-sensitive gatekeeper. Enhanced dispersity, high drug loading capacity, long-circulation time, pH-triggered targeting, and better cellular uptake of the multifunctional MSNs make them potential candidates for pH-sensitive drug delivery such as tumor therapy.
Starting Page	55
Ending Page	58
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1021/acsmacrolett.5b00765
Volume Number	5
Alternate Webpage(s)	http://www.meplab.fudan.edu.cn/d/file/infonet/assays/2017-09-28/ce534cd96d8c4c45fd4f9002d7b95d31.pdf
Alternate Webpage(s)	https://doi.org/10.1021/acsmacrolett.5b00765
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article