NDLI: Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors.

Please wait, while we are loading the content...

Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors.

Content Provider	Semantic Scholar
Author	Hanke, Thomas Takizawa, Hisao McMahon, Christopher W. Busch, Dirk H. Pamer, Eric G. Miller, Joseph I. Altman, John D. Liu, Yuexin Cado, Dragana Lemonnier, François A. Bjorkman, Pamela J. Raulet, David H.
Copyright Year	1999
Abstract	Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a semiquantitative cell-cell adhesion assay as well as class I/peptide tetramers to provide a comprehensive analysis of specificities of Ly49 receptors for class I MHC molecules in eight MHC haplotypes. Different Ly49 receptors exhibited diverse binding properties. The degree of class I binding was related to the extent of functional inhibition. The tetramer studies demonstrated that neither glycosylation nor coreceptors were necessary for class I binding to Ly49 receptors and uncovered peptide-specific recognition by a Ly49 receptor. The results provide a foundation for interpreting and integrating many existing functional studies as well as for designing tests of NK cell development and self-tolerance.
Starting Page	67
Ending Page	77
Page Count	11
File Format	PDF HTM / HTML
DOI	10.1016/S1074-7613(00)80082-5
PubMed reference number	10435580
Journal	Medline
Volume Number	11
Issue Number	1
Alternate Webpage(s)	http://mcb.berkeley.edu/labs2/raulet/sites/mcb.berkeley.edu.labs2.raulet/files/u7/Hanke%20direct%209907%20Imm.pdf
Alternate Webpage(s)	https://doi.org/10.1016/S1074-7613%2800%2980082-5
Journal	Immunity
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in