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Role of the brain heme oxygenase-carbon monoxide pathway in stress fever in rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Steiner, Alexandre A. Reste, Gustavo Branco, Luiz G. S. |
| Copyright Year | 2003 |
| Abstract | This study was aimed at testing the hypothesis that the brain heme oxygenase (HO)-carbon monoxide (CO) pathway plays a role in stress fever. To this end, the effect of the HO inhibitor, zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG), on restraint-induced fever was tested. Intracerebroventricular ZnDPBG (200 nmol) did not affect the body core temperature of unrestrained rats, but markedly attenuated restraint-induced fever. However, at the same dose, intraperitoneal ZnDPBG did not affect the febrile response to restraint. Taken together, these results indicate that the brain HO-CO pathway plays a major role in the genesis of stress fever in rats. |
| Starting Page | 193 |
| Ending Page | 196 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0304-3940(03)00197-6 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304394003001976 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304394003001976?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 12697281 |
| Alternate Webpage(s) | https://doi.org/10.1016/S0304-3940%2803%2900197-6 |
| Journal | Medline |
| Volume Number | 341 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
