NDLI: Bioinformatics Approaches for the Identification and Annotation of RNA Editing Sites

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Bioinformatics Approaches for the Identification and Annotation of RNA Editing Sites

Content Provider	Semantic Scholar
Author	Lee, Soo Youn Kim, Ju Han
Copyright Year	2013
Abstract	deletion editing (insertion or deletion of nucleotides). With the development of high-throughput next-generation sequencing technologies, increasing numbers of RNA editing sites are rapidly being discovered. Accordingly, many bioinformatics tools and algorithms to identify novel RNA editing sites and semantic annotation of known information are increasingly being introduced. Each method, however, is not free from limitations. For example, numerous false positives are found in the newly discovered sites. 2-4) It is in part due to the limitation of the currently available highthroughput sequencing technologies and in part due to the incompleteness of bioinformatics analysis methods. This review summarizes modern bioinformatics approaches that discover and annotate RNA editing sites. Analytic methods do not work alone solely on RNA sequencing data. This review also includes the strategic steps used in the analysis of RNA editing, related bioinformatics resources that are useful in the analysis of RNA editing and methods to compare the analysis to further improve the analysis results. Bioinformatics Approaches for the Identification and Annotation of RNA Editing Sites
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://pdf.medrang.co.kr/JGM/2013/010/JGM-10-027.pdf
Alternate Webpage(s)	http://www.snubi.org/~juhan/pubFiles/RNAEditing.pdf
Language	English
Access Restriction	Open
Subject Keyword	Annotation Benchmark (computing) Bioinformatics Biopolymer Sequencing Chamaecyparis lawsoniana Deletion Mutation Experiment High-throughput computing Insertion Mutation Knowledge Bases Knowledge base Massively-Parallel Sequencing Nucleotides RNA Editing Test Drive Throughput Transcript Transcription, Genetic algorithm
Content Type	Text
Resource Type	Article

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