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An immunocytochemical study of mitochondrial manganese-superoxide dismutase in the rat hippocampus after kainate administration
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kim, Hyoung-Chun Jhoo, Wang-Kee Kim, Won-Ki Suh, Jeong-Hye Ko, Kwang Ho |
| Copyright Year | 2000 |
| Abstract | We examined the immunocytochemical distribution of mitochondrial Mn-superoxide dismutase (SOD-2) in the rat hippocampus after systemic injection of kainic acid (KA), in order to understand SOD-2-responsible antioxidant defense mechanism during the neurodegenerative process. SOD-2 immunostaining was more intense in CA3 pyramidal neurons than in CA1 neurons in the normal hippocampus. The immunoreactivity in region CA1 was reduced without significant neuronal losses within 12 h of KA injection. The CA1 and CA3 neurons lost their immunoreactivity, whereas SOD-2-positive glia-like cells proliferated, mainly throughout the CA1 sector, and had intense immunoreactivity 3 and 7 days after KA injection. This immunocytochemical distribution of SOD-2-positive non-neuronal elements was similar to that of glial fibrillary acidic protein (GFAP) and S-100 protein-positive cells. Activated microglial cells selectively marked with lectin occurred in the areas affected by the KA-induced lesion. Double-labeling immunocytochemistry showed the co-localization of SOD-2-positive non-neuronal cells and GFAP or S-100 protein-like immunoreactivity in the same cells. This suggests that astroglial cells mobilized to synthesize of SOD-2 protein in a response to KA toxicity designed to reduce the oxidative damage. |
| Starting Page | 65 |
| Ending Page | 68 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0304-3940(99)00969-6 |
| PubMed reference number | 10686417 |
| Journal | Medline |
| Volume Number | 281 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304394099009696 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304394099009696?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0304-3940%2899%2900969-6 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
