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Effect of Dialkyl Ammonium Cationic Surfactants on the Microfluidity of Membranes Containing Raft Domains.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Uyama, Makoto Inoue, Kaori Kinoshita, Koichi Miyahara, Reiji Yokoyama, Hirokazu Nakano, Minoru |
| Copyright Year | 2018 |
| Abstract | It has been reported that a lot of receptors localize in lipid raft domains and that the microfluidity of these domains regulates the activation of these receptors. In this study, we focused on the lipid raft and in order to evaluate the physicochemical effects of surfactants on microfluidity of lipid membranes, we used liposomes comprising of egg-yolk L-α-phosphatidylcholine, egg-yolk sphingomyelin, and cholesterol as a model of cell membranes containing raft domains. The microfluidity of the domains was characterized by fluorescence spectrometry using 1,6-diphenyl-1,3,5-hexatriene and 2-dimethylamino-6-lauroylnaphthalene. Among several surfactants, dialkylammonium-type cationic surfactants most efficiently increased the microfluidity. It is therefore concluded that (1) the electrostatic interaction between the cationic surfactant and eggPC/eggSM/cholesterol liposome could be important, (2) surfactants with alkyl chains more effectively inserted into membranes than those with acyl chains, and (3) cationic surfactants with lower Tm values have a greater ability to increase the fluidity. |
| Starting Page | 67 |
| Ending Page | 75 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/jos/67/1/67_ess17124/_pdf/-char/en |
| PubMed reference number | 29311523v1 |
| Alternate Webpage(s) | https://doi.org/10.5650/jos.ess17124 |
| DOI | 10.5650/jos.ess17124 |
| Journal | Journal of oleo science |
| Volume Number | 67 |
| Issue Number | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Ammonium Chloride Cholesterol Clinical act of insertion Diphenylhexatriene Lipid Metabolism Disorders Liposomes Plasma membrane Spectrometry Spectrometry, Fluorescence Sphingomyelins Tissue membrane alkyl yolk |
| Content Type | Text |
| Resource Type | Article |
