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NMDA receptor CTD truncations 1 C-terminal Domains of NMDA ( N-Methyl-D-aspartic Acid ) Receptor Modulate Unitary Channel Conductance and Gating
| Content Provider | Semantic Scholar |
|---|---|
| Author | Maki, Bruce A. Aman, Teresa K. Amico-Ruvio, Stacy A. Kussius, Cassandra L. Popescu, Gabriela K. |
| Copyright Year | 2012 |
| Abstract | Background: The C-terminal domains (CTDs) of NMDA receptors are essential for normal brain function. Results: We developed kinetic mechanisms for receptors lacking CTDs using single-channel methods. Conclusion: GluN1 CTDs control primarily unitary conductance and GluN2 CTDs control gating kinetics. Significance: Results afford quantitative insight into how intracellular perturbations can change the time course of NMDA receptor currents. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jbc.org/content/early/2012/09/04/jbc.M112.390013.full.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |