NDLI: A modular chitin-binding protease associated with hemocytes and hemolymph in the mosquito Anopheles gambiae.

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A modular chitin-binding protease associated with hemocytes and hemolymph in the mosquito Anopheles gambiae.

Content Provider	Semantic Scholar
Author	Danielli, Alberto Loukeris, Thanasis G. Lagueux, Marie Müller, Helena Richman, Alex Kafatos, Fotis C.
Copyright Year	2000
Abstract	Sp22D, a modular serine protease encompassing chitin binding, low density lipoprotein receptor, and scavenger receptor cysteine-rich domains, was identified by molecular cloning in the malaria vector, Anopheles gambiae. It is expressed in multiple body parts and during much of development, most intensely in hemocytes. The protein appears to be posttranslationally modified. Its integral, putatively glycosylated form is secreted in the hemolymph, whereas a smaller form potentially generated by proteolytic processing is associated with the tissues. Bacterial challenge or wounding result in low-level RNA induction, but the protein does not bind to bacteria, nor is its processing affected by infection. However, Sp22D binds to chitin with high affinity and undergoes transient changes in processing during pupal to adult metamorphosis; it may respond to exposure to naked chitin during tissue remodeling or damage.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.97.13.7136
PubMed reference number	10860981
Journal	Medline
Volume Number	97
Issue Number	13
Alternate Webpage(s)	http://www.pnas.org/content/97/13/7136.full.pdf
Alternate Webpage(s)	https://doi.org/10.1073/pnas.97.13.7136
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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