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Densidad mineral ósea en pacientes premenopáusicas con depresión: Relación con los niveles séricos de cortisol, proteina c reactiva y marcadores óseos
| Content Provider | Semantic Scholar |
|---|---|
| Author | Guerrero, U. Yorly J. Uzcátegui, Lilia Torres, Adrián Escalante, Karen Acosta, Marta |
| Copyright Year | 2010 |
| Abstract | Objective: To evaluate BMD in premenopausal women with and without depression and its relationship to serum cortisol, C-reactive protein (CRP) and bone markers. Methods: An observational study, cross-sectional, analytical, case-control sub-model, was conducted. The study included 40 premenopausal women (between 30 and 45 years), 20 with depression, using the criteria of the 17-item Hamilton Rating Scale for Depression (HAM-D), and 20 healthy controls. Cortisol, us-CRP and bone markers (osteocalcin and s cross laps) serum levels were quantified. Spine and hip BMD, using Lunar DXA machine, was performed. Results: The mean age was 39,40 ± 4,79 years for cases and 39,20 ± 5,63 for controls; BMI 27,36 kg/m2 for both groups. There were not significant differences in clinical characteristics. BMD of the spine and hip were significantly lower in depressed than in nondepressed women (1,132 ± 0,10 vs 1,215 ± 0,14 p <0,045 and 0,991±0,13 vs 1,090 p<0,012 respectively). It made the crossing of the Hamilton Test results with bone markers, cortisol, us-CRP, and spine and hip BMD; there was a lower hip BMD in patients with depression (p = 0,002). There were not differences in biochemical variables. Conclusion: Our findings suggest that depression is a significant risk factor for low bone mass in premenopausal women. Therefore, periodic evaluations of BMD and prophylactic measures should be promoted in monitoring of these patients. |
| Starting Page | 99 |
| Ending Page | 107 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Volume Number | 8 |
| Alternate Webpage(s) | http://www.saber.ula.ve/bitstream/handle/123456789/32063/articulo2.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
