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The effect of digestion and drug load on absorption of poorly water soluble drugs from self-nanoemulsifying drug delivery systems (SNEDDS)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Michaelsen, Maria Høtoft |
| Copyright Year | 2016 |
| Abstract | Objective: Precipitation of poorly water-soluble dr ugs from lipid-based drug delivery systems (LbDDS) has been studied extensively during i vitro lipolysis, but has never been shown in vivo. The aim of this study was therefore to investigate if drug precipitation can occur from LbDDS during transit of the gastrointestinal-tract in vivo. Methods: Rats were administered 300 μL of either of tw LbDDS (LbDDS I and LbDDS II) loaded with danazol or fenofibrate. The rats were euthani zed at various time points after administration of both LbDDS containing either drug and the contents of the stomach and proximal part of the small intestine were harvested. The contents were analyze d for crystalline drug by x-ray powder diffraction (XRPD) and polarized light microscopy ( PLM). Results: No drug precipitation was evident in the s tomach or the intestine after administration of LbDDS I containing danazol at the tested time point s. Fenofibrate precipitation was absent in the stomach initially after administration of LbDDS I, but was evident in the stomach 90 min after dosing. No crystalline fenofibrate was observed in the intestine. Danazol and fenofibrate precipitation was evident in the stomach following administration of LbDDS II containg either drug, but not in the intestine at the tested time p oint. Conclusion: Drug precipitation from LbDDS was obser ved in the stomach, but not in the intestine, which is contrary to what in vitro lipolysis data of the tested formulations suggests . Thus precipitation of drugs from LbDDS seems to an artif ct of the in vitro lipolysis model. |
| File Format | PDF HTM / HTML |
| DOI | 10.14288/1.0314313 |
| Alternate Webpage(s) | https://open.library.ubc.ca/media/download/pdf/24/1.0314313/3 |
| Alternate Webpage(s) | https://doi.org/10.14288/1.0314313 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
