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A novel indoloquinoline derivative, IQDMA, induces S-phase arrest and apoptosis in promyelocytic leukemia HL-60 cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hu, Xiu-Wei Chien, Ching-Ming Yang, Sheng-Huei Lin, Yi-Hsiung Lu, Chih-Ming Chen, Yeh-Long Lin, Shinne-Ren |
| Copyright Year | 2006 |
| Abstract | N′-(11H-indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (IQDMA), an indoloquinoline compound, was identified in our laboratory as a novel antineoplastic agent with a broad spectrum of antitumor activity against many human cancer cells. Cell cycle analysis showed S-phase arrest and induction of apoptosis in HL-60 cells following 24 h exposure to IQDMA. Analysis of the cell cycle regulatory proteins demonstrated that IQDMA did not change the steady-state levels of cyclin B1, cyclin D3, and p21, but decreased the protein levels of Cdk1, Cdk2, and cyclin A. IQDMA also caused a marked increase in apoptosis, which was accompanied by increased levels of Bax, activated caspase-3, -8, and -9, and cleaved PARP. These molecular alterations provide an insight into IQDMA-caused growth inhibition, S-phase arrest, and apoptotic death of HL-60 cells. |
| Starting Page | 417 |
| Ending Page | 427 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s10565-006-0098-9 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/s10565-006-0098-9 |
| PubMed reference number | 16906476 |
| Alternate Webpage(s) | https://doi.org/10.1007/s10565-006-0098-9 |
| Journal | Medline |
| Volume Number | 22 |
| Journal | Cell Biology and Toxicology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
