Factores de riesgo para mortalidad en pacientes con infección por Clostridium difficile.

Content Provider	Semantic Scholar
Author	Pérez-Cruz, Elizabeth Sandoval-Flores, María Graciela
Copyright Year	2019
Abstract	Introduction Clostridium difficile infection (CDI) causes potentially lethal diarrhea. Objective To identify the risk factors for mortality in hospitalized patients with CDI. Method Cross-sectional, retrospective study. The analyzed risk factors were age, comorbidities, nutritional status, past and current use of antibiotics, proton pump inhibitors, steroids, immunosuppressive therapy and chemotherapy, as well as development of acute kidney injury (AKI). Results Sixty-eight cases were assessed. Mean age was 51.4 ± 19.37 years. Mortality was 22.2 %. Moderate to severe undernutrition (Odds ratio [OR] = 20.15; 95% confidence interval [CI] = 1.13-35; p = 0.004), use of more than 2 antibiotics (OR = 1.61; 95% CI = 0.39-6.65; p = 0.01), AKI as determined by creatinine levels (OR = 1.34; 95% CI = 0.09-2.21; p = 0.02), hypotension with vasopressor use (OR = 1.28; 95% CI = 0.30-1.23; p = 0.001) and multiple organ failure (OR = 1.13; 95% CI = 0.31-4.92; p = 0.002) were associated with mortality. Conclusions CDI represents an important problem in hospitalized patients and confers them an additional morbidity and mortality risk.
Starting Page	343
Ending Page	349
Page Count	7
File Format	PDF HTM / HTML
DOI	10.24875/GMM.19004345
PubMed reference number	31486783
Journal	Medline
Volume Number	155
Issue Number	4
Alternate Webpage(s)	http://gacetamedicademexico.com/files/gmm_19_155_4_343-349.pdf
Alternate Webpage(s)	https://doi.org/10.24875/GMM.19004345
Journal	Gaceta medica de Mexico
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article