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Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Erb, Suzanne M. Funk, Douglas Borkowski, Sandra Watson, Stanley J. Akil, Huda |
| Copyright Year | 2004 |
| Abstract | The neuropeptide, corticotropin-releasing hormone (CRH), has been shown to play a role in behavioral and neurobiological effects of drugs of abuse. An important modulator of CRH, the CRH binding protein (CRH-BP), has not, on the other hand, been assessed for its role in drug-associated effects. The primary objective of the present experiment was to assess whether prior, chronic exposure to cocaine modulates expression of CRH-BP, and to compare expression of the BP with that of the peptide itself. We assessed CRH-BP and CRH mRNA expression in two brain regions where CRH is known to affect responses to drugs of abuse; namely, the central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST). Male Long-Evans rats were given 14 daily injections of cocaine (30 mg/kg, i.p.) or saline. One, 3, 10, 28, or 42 days post-treatment, animals were killed and adjacent brain sections through the CeA and BNST were processed for CRH-BP and CRH by in situ hybridization. In the CeA, cocaine pre-exposure increased both CRH and CRH-BP mRNA expression 1 day post-treatment. In the dorsal BNST, cocaine pre-exposure elevated levels of CRH-BP, but not CRH, mRNA 3 days post-treatment. Taken together, the results suggest that withdrawal-induced changes in the expression of the CRH-BP, and CRH itself, are relatively short-lived and that a dysregulation in basal expression of either gene is not likely responsible for long-lasting behavioral effects noted with cocaine and other drugs of abuse. |
| Starting Page | 1003 |
| Ending Page | 1009 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neuroscience.2003.10.031 |
| PubMed reference number | 14751291 |
| Journal | Medline |
| Volume Number | 123 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0306452203008376 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0306452203008376?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neuroscience.2003.10.031 |
| Journal | Neuroscience |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
