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Synthesis and Relaxivity Measurement of Cyclen Based Magnetic Resonance Imaging (mri) Contrast Agent
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rashid, Haroon Ur Khan, Khalid Mohammed Yaseen, Muhammad Na, Waseem H. A. S. S. A. Rc, Muhammad Naveed U. M. A. |
| Copyright Year | 2014 |
| Abstract | 1, 4, 7, 10-teraazacyclododecane (cyclen) is a key macrocycle used for the synthesis of Magnetic Resonance Imaging (MRI) contrast agents. Substituting the hydrogen atoms (attached to the nitrogen atoms in the ring) of cyclen with suitable groups produce stable ligands. These ligands on complexation with Ln ions lead to the formation of useful chelates. Cyclen is widely synthesized via Richman and Atkins method. Cyclen based ligand 1,4,7-tris(carboxymethyl)-10-(methyl,2-ethoxybenzoate)1,4,7,10-tetraazacyclododecane (DO3A-MEB) was synthesized in this work. It was subsequently coupled with Gd ion to afford its stable complex. Relaxivity of the complex was measured by inversion recovery (IR) method and it was compared with that of the commonly used MRI contrast agent Gd-DTPA. Longitudinal relaxivity measurements indicated 128 % enhancement compared to Gd-DTPA. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://revroum.lew.ro/wp-content/uploads/2014/1/Art%2004.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
