Loading...
Please wait, while we are loading the content...
The urokinase-streptokinase pulmonary embolism trial (phase II) results.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bell, William R. Simon, Toby L. Stengle, James M. Sherry, Sol |
| Copyright Year | 1974 |
| Abstract | IN 1967 the National Heart and Lung Institute organized a multi-institutional controlled clinical trial to evaluate thrombolytic agents in the treatment of pulmonary embolism.' The results of the first phase of that study (The Urokinase Pulmonary Embolism Trial) showed that 12 hours of urokinase compared to heparin and oral anticoagulants alone increased the resolution rate of pulmonary thromboemboli, especially massive emboli, as judged by arteriography, hemodynamics, and lung scanning, assessed within 24 hours of therapy.2 3 4 Serial lung scanning revealed that these differences in embolus resolution rates decreased when assessed at 14 days.4 A second phase (The Urokinase-Streptokinase Pulmonary Embolism Trial), recently completed and reported in more detail in the Journal of the American Medical Association,5 compares 12 hours of urokinase to 24 hours of urokinase and to 24 hours of streptokinase. One hundred sixty-seven patients who satisfied the clinical criteria for embolism within five days of treatment and the specific angiographic criteria applied by |
| Starting Page | 1 |
| Ending Page | 6 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/50/6/1070.full.pdf |
| PubMed reference number | 4430106v1 |
| Volume Number | 50 |
| Issue Number | 6 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anticoagulants Arteriography Fibrinolytic Agents Idiopathic Pulmonary Fibrosis Numerous Patients Pulmonary Embolism Streptokinase Structure of parenchyma of lung Urokinase heparin |
| Content Type | Text |
| Resource Type | Article |
