NDLI: Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines

Content Provider	Semantic Scholar
Author	Jiang, Wei
Abstract	The present study aimed to investigate the mechanisms of ATO to treat hepatocellular carcinoma (HCC) and seek potential combinational options. The authors analyzed the effects of ATO in combination with 5-FU or sorafenib respectively on HepG2 and LX-2 cell lines and concluded that ATO in combination with 5-FU or sorafenib have enhanced cytotoxicity in HepG2 for the decrease in thymidylate synthase by ATO and the potent inhibition of MAPK activation by sorafenib.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://static-content.springer.com/openpeerreview/art:10.1186%2F1471-2407-12-402/12885_2012_3430_ReviewerReport_V1_R1.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Report

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