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Prenatal PCB exposure, the corpus callosum, and response inhibition.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Stewart, Paul W. Fitzgerald, Susan M. Reihman, Jacqueline Gump, Brooks B. Lonky, Edward I. Darvill, Thomas J. Pagano, Jim Hauser, Péter |
| Copyright Year | 2003 |
| Abstract | The present study reports the association between prenatal exposure to polychlorinated biphenyls (PCBs), the corpus callosum, and response inhibition in children who are 4.5 years old. Children (n = 189) enrolled in the Oswego study were tested using a continuous performance test. We measured (square millimeters) the splenium of the corpus callosum, a pathway implicated in the regulation of response inhibition, using magnetic resonance imaging. Results indicated a dose-dependent association between cord blood PCBs and errors of commission. Splenium size but not other brain areas predicted errors of commission (r(2) = 0.20), with smaller size associated with more errors of commission. There was an interaction between splenium size and PCB exposure. The smaller the splenium, the larger the association between PCBs and errors of commission. If the association between PCBs and response inhibition is indeed causal, then children with suboptimal development of the splenium are particularly vulnerable to these effects. These data await replication. |
| Starting Page | 1670 |
| Ending Page | 1677 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 14527849 |
| Volume Number | 111 |
| Journal | Environmental health perspectives |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Body of uterus CNS disorder Composite Score Corpus Callosum Correlative Study Evaluation procedure Hematological Disease Inhibition Large Magnetic Resonance Imaging Meles Polychlorinated Biphenyls Primates Procarbazine Small Umbilical Cord Blood millimeter |
| Content Type | Text |
| Resource Type | Article |
