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Absorption, excretion, and distribution of plant sterols after proximal gut resection and autotransplantation of porcine ileum
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pakarinen, Mikko P. Halttunen, Jorma Kuusanmäki, Pekka Lauronen, Jouni Miettinen, Tatu A. |
| Copyright Year | 1998 |
| Abstract | Contribution of different gut segments to plant sterol absorption, adaptation of plant sterol absorption after partial small bowel resection, and effects of gut transplantation (necessitates extrinsic autonomic denervation and lymphatic disruption) on plant sterol biodynamics are unclear. We studied the consequences of massive proximal small bowel resection and autotransplantation of the remaining ileum on the adaptive absorption and biodynamics of plant sterols. Dietary, fecal, biliary, hepatic and plasma plant sterols, fecal elimination and absorption of cholesterol, small bowel morphology, and intestinal transit were determined before (n=5) and at 4, 8, and 14 wk after resection of the proximal 75% of the jejunoileum (n=15) and autotransplantation of the remaining ileum (n=15) or transection (n=5). Proximal gut resection significantly reduced cholesterol absorption efficiency; percentage absorption and biliary secretion of plant sterols; plasma, biliary and hepatic campesterol-to-cholesterol proportions; and sitosterol proportions in plasma and bile. Autotransplantation of the remaining ileum further significantly decreased cholesterol absorption efficiency; percentage absorption and biliary secretion of campesterol; campesterol proportions in plasma, bile and liver; and plasma proportions of sitosterol while increasing fecal excretion of neutral and acidic steroids. Plasma proportions of the two plant sterols, but absorption of just campesterol, were gradually improved with increasing cholesterol absorption and villus height after proximal gut resection; the same result was observed to a lesser degree after ileal autotransplantation. In addition, significant positive correlations were found between percentage cholesterol and campesterol absorption and the plasma plant sterol proportions in both proximal resection groups, between campesterol absorption and ileal villus height in the resection group, and between campesterol absorption and intestinal transit time in the autotransplantation group. In conclusion, plasma campesterol and sitosterol closely reflect absorption of cholesterol and plant sterols from intact and autotransplanted ileum during adaptation to proximal gut resection. A loss of proximal gut absorptive surface impairs cholesterol and campesterol absorption more than sitosterol absorption, the later being apparently less dependent on available jejunal villus surface area. |
| Starting Page | 267 |
| Ending Page | 276 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s11745-998-0205-y |
| PubMed reference number | 9560801 |
| Journal | Medline |
| Volume Number | 33 |
| Alternate Webpage(s) | https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/s11745-998-0205-y |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/s11745-998-0205-y |
| Alternate Webpage(s) | https://doi.org/10.1007/s11745-998-0205-y |
| Journal | Lipids |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
