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Sacran Hydrogel Film Containing Keratinocyte Growth Factor Accelerates Wound Healing by Stimulating Fibroblast Migration and Re-epithelization.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wathoni, Nasrul Rusdiana, Taofik Hasanah, Aliya Nur Muhtadi, Ahmad Pratiwi, Elasari Dwi Mahmudah, Ripa'tul Mohammed, Ahmed Fouad Abdelwahab Okajima, Maiko Kaneko Kaneko, Tatsuo Arima, Hidetoshi |
| Copyright Year | 2019 |
| Abstract | Regenerative therapy with keratinocyte growth factor (KGF) is a novel therapeutic approach for treatment of chronic wounds. However, KGF cannot be used directly to the wound site due to its physicochemical instability. In previous study, sacran, a natural megamolecular polysaccharide, showed potential properties as a biomaterial for hydrogel film in wound healing. In this study, we fabricated sacran hydrogel film containing KGF (Sac/KGF-HF) and evaluated the effects of Sac/KGF-HF on fibroblasts migration and re-epithelialization process. We successfully prepared a homogenous and -amorphous Sac/KGF-HF by a casting method. In addition, Sac/KGF-HF had a high swelling ratio and flexibility. Sac/KGF-HF promoted a migration process of NIH3T3 cells and improved wound healing ability in mice with a percentage of wound closure reaching 90.4% at 9 d. Interestingly, the addition of KGF in Sac-HF considerably increased the number of epithelial cells compared to control, which is important in the re-epithelialization process. It could be concluded that KGF in Sac-HF has the potential for promoting Sac-HF abilities in wound healing process. |
| Starting Page | 849 |
| Ending Page | 854 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1248/cpb.c19-00291 |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/cpb/67/8/67_c19-00291/_pdf/-char/ja |
| PubMed reference number | 31366834 |
| Alternate Webpage(s) | https://doi.org/10.1248/cpb.c19-00291 |
| Journal | Medline |
| Volume Number | 67 |
| Issue Number | 8 |
| Journal | Chemical & pharmaceutical bulletin |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
