NDLI: The induction of corticosteroid actions on membrane properties of hippocampal CA1 neurons requires protein synthesis

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The induction of corticosteroid actions on membrane properties of hippocampal CA1 neurons requires protein synthesis

Content Provider	Semantic Scholar
Author	Karst, Henk Joëls, Marian
Copyright Year	1991
Abstract	Corticosterone can affect electrical properties of CA1 pyramidal neurons via binding to two corticoid receptor types, the mineralocorticoid (MR) and glucocorticoid receptor (GR). Previously we have shown that MR-activation leads to attenuation of serotonin (5-HT)-induced membrane hyperpolarization, while GR-activation induces an increase in the amplitude of the afterhyperpolarization (AHP) following a short current pulse. In this study we show that the MR- and GR-mediated changes of the membrane properties are prevented in the presence of the protein synthesis inhibitor cycloheximide, thus suggesting a genomic action of the steroids.
Starting Page	27
Ending Page	31
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(91)90219-J
PubMed reference number	1660971
Journal	Medline
Volume Number	130
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/030439409190219J
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/030439409190219J?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2891%2990219-J
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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