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Vinorelbine Plus Cisplatin for Advanced Non-small-cell Lung Cancer
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mori, Kiyoshi |
| Copyright Year | 2003 |
| Abstract | \This paper reviews the clinical outcomes presently achieved for the combination regimen of vinorel bine (VNR)plus cisplatin (CDDP)in advanced non-small-cell lung cancer (NSCLC) .The combination regimen(VC) was more effective than VNR alone, CDDP alone, or CDDP plus old drugs . The results were almost identical to those obtained for combination regimens of platinum plus other new drugs . The main adverse reactions were neutropenia and nausea/vomiting. Quality of life on VC was equivalent to that on platinum plus other new drugs. In terms of convenience , weekly VNR+ CDDP (every 4 weeks) was inferior to paclitaxel + carboplatin (PCb) but appeared to be equivalent to VC every 3 weeks . The VC regimen is less expensive than PCb . There are problems with the dosing schedule of VNR in VC however , with VNR delivered on day 15 in less than 50% of patients receiving a regimen of VNR 25 mg/m2 (weekly) and CDDP 80 mg/ m2 (day 1) every 4 weeks. In contrast, analysis of data including that in our study revealed that the median delivered dose intensity was at least 90% for each course of CDDP and VNR (days 1 and 8) in a regimen of VNR 25 mg/m2 (days 1 and 8), CDDP 80 mg/m2 (day 1) every 3 weeks , showing that VNR was administered almost in accordance with the schedule. The clinical outcome in a 3-weekly dosing schedule was a response rate of 29 to 57% , and mean survival was approximately 10 months. VC administered in a 3-weekly dosing schedule is therefore recommended . (JJLC. 2003;43: 872-876) KEY WORDS•\Non-small cell lung cancer, Vinorelbine , Cisplatin 1 栃 木 県 立 が んセ ン ター呼 吸 器科 . 別 刷 請 求先:森 清志,栃 木 県 立 が んセ ン ター呼 吸 器科,〒320一 0834栃 木 県 宇 都 宮 市 陽 南4-9-13(e-mail: kmori@tcc. pref. tochigi . jp). 1Department of Thoracic Diseases , Tochigi Cancer Center, Japan. Reprints:,(e-mail: kmori@tcc. pref. tochigi. jp). (C)2003 The Japan Lung Cancer Society 872 Japanese Journal of Lung Cancer—Vol-43 , No 7, Dec 20, 2003-www. haigan. gr. jp VNR Plus CDDP for Advanced NSCLC-Mori |
| Starting Page | 872 |
| Ending Page | 876 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.2482/haigan.43.872 |
| Volume Number | 43 |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/haigan1960/43/7/43_7_872/_pdf |
| Alternate Webpage(s) | https://doi.org/10.2482/haigan.43.872 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
