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Endomorphin-1 reduces carrageenan-induced Fos expression in the rat spinal dorsal horn
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Yi-Qing |
| Copyright Year | 1999 |
| Abstract | Intraplantar injection of carrageenan induced significant Fos expression in the superficial and deep spinal dorsal horn at the L(4)-L(5)segments and extensive peripheral edema of the ipsilateral foot in rats. Intraplantar injection of endomorphin-1, endogenous ligand for mu opioid receptor, in the same region produced dose-dependent reduction of carrageenan-induced Fos expression and peripheral edema, which were completely blocked by co-administration of intraplantar injection of naloxone (20 microgram). The systemic injection of the highest dose of endomorphin-1 (50 microgram) had no significant reductory effect on Fos expression and peripheral edema. These results further provided a strong evidence for involvement of mu opioid receptor in peripheral analgesia, particularly in inflammation pain. |
| Starting Page | 281 |
| Ending Page | 284 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1054/npep.1999.0040 |
| PubMed reference number | 10657505 |
| Journal | Medline |
| Volume Number | 33 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0143417999900409 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0143417999900409?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1054/npep.1999.0040 |
| Journal | Neuropeptides |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
