NDLI: Zinc-Chelating Mechanism of Sea Cucumber (Stichopus japonicus)-Derived Synthetic Peptides

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Zinc-Chelating Mechanism of Sea Cucumber (Stichopus japonicus)-Derived Synthetic Peptides

Content Provider	Semantic Scholar
Author	Liu, Xiaoyang Wang, Zixu Yin, Fawen Liu, Yuxin Qin, Ningbo Nakamura, Yoshimasa Shahidi, Fereidoon Yu, Chenxu Zhou, Dayong Zhu, Beiwei
Copyright Year	2019
Abstract	In this study, three synthetic zinc-chelating peptides (ZCPs) derived from sea cucumber hydrolysates with limited or none of the common metal-chelating amino-acid residues were analyzed by flame atomic absorption spectroscopy, circular dichroism spectroscopy, size exclusion chromatography, zeta-potential, Fourier transform infrared spectroscopy, Raman spectroscopy and nuclear magnetic resonance spectroscopy. The amount of zinc bound to the ZCPs reached maximum values with ZCP:zinc at 1:1, and it was not further increased by additional zinc presence. The secondary structures of ZCPs were slightly altered, whereas no formation of multimers was observed. Furthermore, zinc increased the zeta-potential value by neutralizing the negatively charged residues. Only free carboxyl in C-terminus of ZCPs was identified as the primary binding site of zinc. These results provide the theoretical foundation to understand the mechanism of zinc chelation by peptides.
File Format	PDF HTM / HTML
DOI	10.3390/md17080438
PubMed reference number	31349695
Journal	Medline
Volume Number	17
Journal	Marine drugs
Alternate Webpage(s)	https://res.mdpi.com/d_attachment/marinedrugs/marinedrugs-17-00438/article_deploy/marinedrugs-17-00438-v2.pdf
Alternate Webpage(s)	https://doi.org/10.3390/md17080438
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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