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Degradation of morpholine-2, 5-dione derivative copolymer in Vitro
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhao, Yanchao Hu, Yuanjun Cheng, Shujun Chen, Jingyuan |
| Copyright Year | 2008 |
| Abstract | AbstractDegradation of Poly (L-lactide-co-glycolic acid-co-β-Benzyl-L-aspartate) [P(LLA-BMD)] in vitro was carried out in phosphate buffer solution (PBS) at 37 °C for 90 days. Poly (L-lactide-co-glycolide) (PLGA) was used as the control sample. Using gravimetric (weight loss) method, scan electron microscope (SEM), FT-IR, 1H-NMR, Gel permeation chromatography (GPC) and contact angel test as the testing methods, the degradation properties of this copolymer were obtained. The results showed that the copolymer of morpholine-2,5-dione derivative and L-lactide had a lower contact angel (74o) and slower degradation rate than that of PLGA. Under the current experimental conditions the degradation mechanism of P(LLA-BMD) is probably bulk degradation, being the same as PLGA. And the degradation of P(LLA-BMD) was more easily to be under control than PLGA, what’s more, the mole composition had hardly changed ( from nLLA:nBMD=83/17 to 85/15 in 90 days). It would be served as a potential candidate material in the delivery of water-soluble drugs. |
| Starting Page | 35 |
| Ending Page | 41 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s00289-008-0924-8 |
| Volume Number | 61 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/s00289-008-0924-8 |
| Alternate Webpage(s) | https://doi.org/10.1007/s00289-008-0924-8 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
