NDLI: A nonsteroid anti-inflammatory drug exacerbates Coxsackie B3 murine myocarditis.

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A nonsteroid anti-inflammatory drug exacerbates Coxsackie B3 murine myocarditis.

Content Provider	Semantic Scholar
Author	Costanzo-Nordin, Maria Rosa Reap, E. A. O'connell, John B. Robinson, John Alan Scanlon, Patrick J.
Copyright Year	1985
Abstract	Nonsteroid anti-inflammatory drugs are often used to treat myalgias and arthralgias in enteroviral infections, but their effects on acute viral myocarditis are unknown. The effect of the nonsteroidal anti-inflammatory drug, ibuprofen, on acute viral myocarditis was studied in 75 four week old male BALB/c mice infected with 1.75 X 10(7) plaque-forming units of Coxsackie virus B3 on day 0. Ibuprofen was given intraperitoneally at a dose of 15 mg/kg body weight daily. The mice were assigned to four groups--Group I, 18 uninfected mice given ibuprofen on days 1 to 14; Group II, 18 infected, untreated mice; Group III, 20 infected mice given ibuprofen on days 1 to 14; and Group IV, 17 infected mice given ibuprofen on days 7 to 14. Nine animals in Group I, eight in Group II and seven in Group III were killed on day 7; the remaining mice were killed on day 14. Heart viral cultures and histologic analysis were done. Cultures at days 7 and 14 were all negative. Inflammation and necrosis analyzed in each animal were graded 0 to 4, with grade 4 representing widespread inflammation and necrosis. The heart was histologically normal in all 18 uninfected mice (Group I) given ibuprofen only. Inflammation and necrosis were not significantly different in Group II (infected, untreated) and Group III (infected, treated beginning day 1) mice killed at day 7. Inflammation scores of mice killed on day 14 were 2.1 +/- 0.6 (Group II), 3.1 +/- 0.7 (Group III) and 2.9 +/- 1.0 (Group IV infected, treated days 7 to 14).(ABSTRACT TRUNCATED AT 250 WORDS)
Starting Page	95
Ending Page	109
Page Count	15
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://core.ac.uk/download/pdf/82030501.pdf
PubMed reference number	2995470v1
Volume Number	6
Issue Number	5
Journal	Journal of the American College of Cardiology
Language	English
Access Restriction	Open
Subject Keyword	Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Arthralgia Dental Plaque Enterovirus Infections Ibuprofen Myalgia Necrosis PersonNameUse - assigned Viral myocarditis
Content Type	Text
Resource Type	Article

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