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Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma
| Content Provider | Semantic Scholar |
|---|---|
| Author | Feng, Yong Shen, Jacson K. Liao, Yunfei Cote, Gregory M. Choy, Edwin Chebib, Ivan Mankin, Henry J. Hornicek, Francis Duan, Zhenfeng |
| Copyright Year | 2015 |
| Abstract | Chordomas are primary malignant tumors of the notochord that are resistant to conventional chemotherapy. Expression of programmed cell death ligand 1 (PD-L1), prevalence of tumor-infiltrating lymphocytes (TILs), and their clinical relevance in chordoma remain unknown. We evaluated PD-L1 expression in three chordoma cell lines and nine chordoma tissue samples by western blot. Immunohistochemical staining was performed on a chordoma tissue microarray (TMA) that contained 78 tissue specimens. We also correlated the expression of PD-L1 and TILs with clinical outcomes. PD-L1 protein expression was demonstrated to be induced by IFN-γ in both UCH1 and UCH2 cell lines. Across nine human chordoma tissue samples, PD-L1 protein was differentially expressed. 94.9% of chordoma samples showed positive PD-L1 expression in the TMA. The expression score of PD-L1 for metastatic chordoma tumors was significant higher as compared with non-metastatic chordoma tumors. Expression of PD-L1 protein significantly correlates with the presence of elevated TILs, which correlates with metastasis. In summary, our study showed high levels of PD-L1 are expressed in chordoma, which is correlated with the prevalence of TILs. The current study suggests targeting PD-L1 may be a novel immunotherapeutic strategy for chordoma clinical trials. |
| Starting Page | 11139 |
| Ending Page | 11149 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.18632/oncotarget.3576 |
| PubMed reference number | 25871477 |
| Journal | Medline |
| Volume Number | 6 |
| Alternate Webpage(s) | https://dash.harvard.edu/bitstream/handle/1/17820945/4484445.pdf?sequence=1 |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/9f/11/oncotarget-06-11139.PMC4484445.pdf |
| Alternate Webpage(s) | https://dash.harvard.edu/bitstream/handle/1/17820945/4484445.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=3576&path%5B%5D=7238 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.3576 |
| Journal | Oncotarget |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
