NDLI: Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 beta-lactamase in korea.

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Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 beta-lactamase in korea.

Content Provider	Semantic Scholar
Author	Jeon, Byung Chan Jeong, Seok Hoon Bae, Il Kwon Kwon, Su Bong Lee, Kyungwon Young, Dongeun Lee, Jung Hun Song, Jae Seok Lee, Sang Hee
Copyright Year	2005
Abstract	We investigated an outbreak of Acinetobacter baumannii in an intensive care unit and in the surgery, medicine, neurology, and urology wards of the Kosin University Gospel Hospital in Busan, Korea. The outbreak involved 36 cases of infection by A. baumannii producing the OXA-23 beta-lactamase over an 8-month period and was caused by a single pulsed-field gel electrophoresis clone. The epidemic isolates were characterized by a modified cloverleaf synergy test. Isoelectric focusing of crude bacterial extracts detected one nitrocefin-positive band with a pI value of 6.65. PCR amplification and characterization of the amplicons by direct sequencing indicated that the epidemic isolates carried a bla(OXA-23) determinant. The epidemic isolates were characterized by a multidrug resistance phenotype that remained unchanged over the outbreak, including penicillins, cephamycins, extended-spectrum cephalosporins, carbapenems, monobactams, and aminoglycosides. This study shows that the bla(OXA-23) resistance determinant may become an emerging therapeutic problem.
Starting Page	1
Ending Page	1
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jcm.asm.org/content/43/5/2241.full.pdf
PubMed reference number	15872249v1
Volume Number	43
Issue Number	5
Journal	Journal of clinical microbiology
Language	English
Access Restriction	Open
Subject Keyword	Aminoglycosides Carbapenems Cephalosporins Cephamycins Clone Direct Sequencing Electrophoresis, Gel, Pulsed-Field Gel Electrophoresis (lab technique) Imipenem Monobactams Multi-Drug Resistance Neurology speciality Penicillins Urology Ward (environment) beta-Lactamase intensive care unit lactamase nitrocefin
Content Type	Text
Resource Type	Article

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