NDLI: Cerebral blood flow in immediate and sustained anxiety.

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Cerebral blood flow in immediate and sustained anxiety.

Content Provider	Semantic Scholar
Author	Hasler, Gregor Fromm, Stephen Alvarez, Ruben P. Luckenbaugh, David A. Drevets, Wayne C. Grillon, Christian
Copyright Year	2007
Abstract	The goal of this study was to compare cerebral blood flow (CBF) changes associated with phasic cued fear versus those associated with sustained contextual anxiety. Positron emission tomography images of CBF were acquired using [O-15]H2O in 17 healthy human subjects as they anticipated unpleasant electric shocks that were administered predictably (signaled by a visual cue) or unpredictably (threatened by the context). Presentation of the cue in either threat condition was associated with increased CBF in the left amygdala. A cue that specifically predicted the shock was associated with CBF increases in the ventral prefrontal cortex (PFC), hypothalamus, anterior cingulate cortex, left insula, and bilateral putamen. The sustained threat context increased CBF in the right hippocampus, mid-cingulate gyrus, subgenual PFC, midbrain periaqueductal gray, thalamus, bilateral ventral striatum, and parieto-occipital cortex. This study showed distinct neuronal networks involved in cued fear and contextual anxiety underlying the importance of this distinction for studies on the pathophysiology of anxiety disorders.
Starting Page	3
Ending Page	8
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/27/23/6313.full.pdf
PubMed reference number	17554005v1
Volume Number	27
Issue Number	23
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Subject Keyword	Amygdaloid structure Anxiety Disorders CFP wt Allele Central gray substance of midbrain Cerebral cortex Cerebrovascular Circulation Cingulate Cortex Electroconvulsive Therapy Gyrus Cinguli Hypothalamus, Anterior Insula of Reil Midbrain structure Neostriatum Positrons Prefrontal Cortex Shock Structure of putamen Thalamic structure Ventral Striatum tomography
Content Type	Text
Resource Type	Article

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