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Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yuen, M. Tanaka, Yasuhito Shinkai, Noboru Poon, Ronnie Tung-Ping But, David Yiu-Kuen Fong, Y. Fung, J. Wong, Danny Ka-Ho Yuen, John Chi-Hang Mizokami, Masashi Lai, - |
| Copyright Year | 2008 |
| Abstract | BACKGROUND/AIM To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. METHODS HBV genotypes, 1653/1753/core promoter (CP)/precore MT and HBV DNA levels were determined in 248 HBV patients with HCC and 248 HBV controls. RESULTS Genotype C, CP-MT, T1653, HBV DNA levels >or=4 log(10) copies/ml and cirrhosis had a higher risk for HCC compared to patients with genotype B (p = 0.001, OR 1.9), CP wild-type (WT) (p<0.001, OR 4.1), C1653 (p = 0.028, OR 2.4), HBV DNA <4 log(10) copies/ml (p = 0.003, OR 2.1) and without cirrhosis (p<0.001, OR 4.0) respectively. Multivariate analysis showed that CP-MT, T1653, HBV DNA >or=4 log(10) copies/ml and cirrhosis were independent factors for HCC (all p<0.05). A receiver operating characteristics curve showed no cut-off HBV DNA level associated with minimal chance of HCC. Patients with CP-MT and cirrhosis had a 22.2-fold increased risk of HCC compared to patients with CP-WT and without cirrhosis. Patients with CP-MT and HBV DNA levels >or=4 log(10) copies/ml had a 7.2-fold increased risk of HCC compared to patients with CP-WT and HBV DNA levels <4 log(10) copies/ml. Patients with CP-MT and T1653 had a 9.9-fold increased risk of HCC compared to patients with wild-type for both regions. CONCLUSIONS CP-MT, T1653, HBV DNA levels >or=4 log(10) copies/ml and cirrhosis are independent factors for development of HCC. The risks increased substantially in patients having these factors in combination. |
| Starting Page | 98 |
| Ending Page | 102 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hub.hku.hk/bitstream/10722/57531/1/134087.pdf |
| PubMed reference number | 17483190v1 |
| Volume Number | 57 |
| Issue Number | 1 |
| Journal | Gut |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cerebral Palsy Copy (object) Enhancer of transcription Fibrosis Genotype Genotyping Techniques Hepatitis B Virus Herpesvirus 1, Cercopithecine Liver carcinoma Mutation Patients Propionibacterium acnes |
| Content Type | Text |
| Resource Type | Article |
