NDLI: Reduced ventilation–perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium‐68 V/Q photon emission tomography/computed tomography

Please wait, while we are loading the content...

Reduced ventilation–perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium‐68 V/Q photon emission tomography/computed tomography

Content Provider	Semantic Scholar
Author	Leong, Paul Roux, Pierre-Yves Le Callahan, Jason William Siva, Shankar Hofman, Michael S. Steinfort, Daniel P.
Copyright Year	2017
Abstract	Endobronchial valves (EBVs) are increasingly deployed in the management of severe emphysema. Initial studies focussed on volume reduction as the mechanism, with subsequent improvement in forced expiratory volume in 1 s (FEV1). More recent studies have emphasized importance of perfusion on predicting outcomes, though findings have been inconsistent. Gallium-68 ventilation-perfusion (V/Q) photon emission tomography (PET)/computed tomography (CT) is a novel imaging modality with advantages in spatial resolution, quantitation, and speed over conventional V/Q scintigraphy. We report a pilot case in which V/Q-PET/CT demonstrated discordant findings compared with quantitative CT analysis, and directed left lower lobe EBV placement. The patient experienced a significant improvement in 6-min walk distance (6MWD) without change in spirometry. Post-EBV V/Q-PET/CT demonstrated a marked decrease in unmatched (detrimental) V/Q areas and improvement in overall V/Q matching on post-EBV V/Q-PET/CT. These preliminary novel findings suggest that EBVs improve V/Q matching and may explain the observed functional improvements.
Starting Page	320
Ending Page	328
Page Count	9
File Format	PDF HTM / HTML
PubMed reference number	28808575v1
Alternate Webpage(s)	https://doi.org/10.1002/rcr2.253
DOI	10.1002/rcr2.253
Journal	Respirology case reports
Volume Number	5
Language	English
Access Restriction	Open
Subject Keyword	Entity Class - imaging modality Expiration, function Forced expiratory volume procedure MATCHING Mitral Valve Prolapse Syndrome Patients Photons Pulmonary Emphysema Pulmonary Function Test/Forced Expiratory Volume 1 Quantitation Radionuclide Imaging Respiration Spirometry Structure of lower lobe of lung Ventilation to Perfusion Ratio X-Linked Lymphoproliferative Disorder X-Ray Computed Tomography
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in