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One-pot synthesis of 2-amino-4(3H)-quinazolinones via ring-opening of isatoic anhydride and palladium-catalyzed oxidative isocyanide-insertion.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lv, Mei-Fang Yi, Wen-Bin Cai, Chun |
| Copyright Year | 2014 |
| Abstract | An efficient and practical two-step process has been developed for the synthesis of 2-amino-4(3H)-quinazolinones via ring-opening of isatoic anhydride and palladium-catalyzed oxidative isocyanide-insertion in one pot. This regioselective procedure could construct a wide range of 2-amino-4(3H)-quinazolinones in moderate to excellent yields. Furthermore, the methodology also had distinct advantages of easily accessible starting materials and operational simplicity. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c4ob00484a |
| Alternate Webpage(s) | http://pubs.rsc.org/en/content/getauthorversionpdf/C4OB00484A |
| PubMed reference number | 24968809 |
| Alternate Webpage(s) | https://doi.org/10.1039/c4ob00484a |
| Journal | Medline |
| Volume Number | 12 |
| Issue Number | 30 |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |