NDLI: treating dehydration due to diarrhoea in children : Reduced osmolarity oral rehydration solution for

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treating dehydration due to diarrhoea in children : Reduced osmolarity oral rehydration solution for

Content Provider	Semantic Scholar
Author	Hahn, Yae Jean Kim Seokyung Garner, Paul
Copyright Year	2001
Abstract	Objectives To compare reduced osmolarity oral rehydration solution with standard World Health Organization oral rehydration solution in children with acute diarrhoea. Design Systematic review of randomised controlled trials. Studies 15 randomised controlled trials including 2397 randomised patients. Outcomes The primary outcome was unscheduled intravenous infusion; secondary outcomes were stool output, vomiting, and hyponatraemia. Results In a meta-analysis of nine trials for the primary outcome, reduced osmolarity rehydration solution was associated with fewer unscheduled intravenous infusions compared with standard WHO rehydration solution (odds ratio 0.61, 95% confidence interval 0.47 to 0.81). Three trials reported that no patients required unscheduled intravenous infusion. Trials reporting secondary outcomes suggested that in the reduced osmolarity rehydration solution group, stool output was lower (standardised mean difference in the log scale − 0.214 (95% confidence interval − 0.305 to − 0.123; 13 trials) and vomiting was less frequent (odds ratio 0.71, 0.55 to 0.92; six trials). Six trials sought presence of hyponatraemia, with events in three studies, but no significant difference between the two arms. Conclusion In children admitted to hospital with dehydration associated with diarrhoea, reduced osmolarity rehydration solution is associated with reduced need for unscheduled intravenous infusions, lower stool volume, and less vomiting compared with standard WHO rehydration solution.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://pmmp.cnki.net/Resources/CDDPdf/evd%5C200801%5CBritish%20Medical%20Journal%5C%E7%B3%BB%E7%BB%9F%E8%AF%84%E4%BB%B7%5Cbmj20013230781.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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