NDLI: Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal.

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Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal.

Content Provider	Semantic Scholar
Author	Mazurek, Michael F. Savedia, S. Bobba, Raja Sekhar Garside, Sarah Rosebush, Patricia I.
Copyright Year	1998
Abstract	A 37 year woman developed neuroleptic induced parkinsonism that persisted long after the drug had been discontinued. This prompted a study of the effect of an eight week course of haloperidol (HAL) followed by two week withdrawal, on dopaminergic neurons of the substantia nigra in rats. Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour. Neuroleptic drug induced downregulation of nigral dopaminergic neurons may help to explain the persistent parkinsonism found in many patients after withdrawal of medication.
Starting Page	799
Ending Page	801
Page Count	3
File Format	PDF HTM / HTML
DOI	10.1136/jnnp.64.6.799
PubMed reference number	9647315
Journal	Medline
Volume Number	64
Issue Number	6
Alternate Webpage(s)	http://jnnp.bmj.com/content/jnnp/64/6/799.full.pdf
Alternate Webpage(s)	https://doi.org/10.1136/jnnp.64.6.799
Journal	Journal of neurology, neurosurgery, and psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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