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Use of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of granulomatous mediastinal lymphadenopathy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Low, Su Ying Koh, Mariko S. Y. Ong, Thun How Phua, Ghee Chee Anantham, Devanand |
| Copyright Year | 2014 |
| Abstract | INTRODUCTION This study assessed the clinical utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the diagnosis of suspected granulomatous mediastinal lymphadenopathy. MATERIALS AND METHODS Retrospective chart review of all patients who underwent EBUS-TBNA for suspected granulomatous mediastinal lymphadenopathy at Singapore General Hospital between December 2008 and December 2011 inclusive. RESULTS Over a period of 3 years, a total of 371 patients underwent EBUS-TBNA of whom 33 (9%) had the procedure performed for evaluation of suspected granulomatous mediastinal lymphadenopathy - 18 for suspected tuberculosis (TB) and non-tuberculous mycobacterial (NTM) lymphadenitis, and 15 for suspected sarcoidosis. EBUS-TBNA was diagnostic in 9 of the 13 patients with a final diagnosis of TB/NTM. EBUS-TBNA cultures were positive in 6 of them (46%), 1 showed acid-fast bacilli (AFB) although cultures were negative, and 2 had necrotising granulomatous inflammation from EBUS-TBNA biopsies and sputum cultures grew TB. EBUS-TBNA was diagnostic in 9 of the 14 patients with a final diagnosis of sarcoidosis through histology showing non-caseating granulomatous inflammation. The sensitivities of EBUS-TBNA for diagnosis of TB/NTM, sarcoidosis and overall granulomatous mediastinal lymphadenopathy were 69%, 64%, 64%; the negative predictive values were 56%, 17%, 33%; and accuracies were 78%, 67%, 70%, respectively. CONCLUSION EBUS-TBNA can be useful in the diagnosis of suspected granulomatous mediastinal lymphadenopathy with sensitivities and accuracies of >60%. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 24919489 |
| Journal | Medline |
| Volume Number | 43 |
| Issue Number | 5 |
| Alternate Webpage(s) | http://www.annals.edu.sg/pdf/43VolNo5May2014/V43N5p250Abstract.pdf |
| Alternate Webpage(s) | http://www.annals.edu.sg/pdf/43VolNo5May2014/V43N5p250.pdf |
| Journal | Annals of the Academy of Medicine, Singapore |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
