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Ganglionitis and genetic cardiac arrhythmias: more questions than answers.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Moss, Arthur J. Ryan, Daniel H. Yeaney, Gabrielle A. |
| Copyright Year | 2014 |
| Abstract | In 1968, Zipes et al1 reported surgical sympathectomy for the control of ventricular tachyarrhythmias in patients with ischemic heart disease. In 1971, our research group reported the effectiveness of surgical left cervicothoracic sympathetic ganglionectomy for the treatment of a patient with long-QT syndrome (LQTS) who experienced recurrent syncope related to ventricular tachyarrhythmias.2 This patient is still alive 43 years later without recurrent cardiac events, and she, her daughter, and her grandson have genotype-confirmed type-1 LQTS. In 1995, we reported the use of this ganglionectomy technique in 10 patients with LQTS.3 In all these patients, the removed lower half of the left stellate ganglion and the second and third left thoracic ganglia were reported as normal by routine histological analysis by our pathologists. Subsequently, this ganglionectomy technique, now called left cardiac sympathetic denervation, has been performed in several arrhythmia centers throughout the world. The major investigators who have reported their ganglionectomy experience in addition to ourselves include Drs Schwartz et al4 and Collura et al,5 and in none of the published reports have ganglionitis been reported in the removed stellate or thoracic ganglia. Article see p 224 In the current publication by Rizzo et al6 from the Amsterdam group, the lower half of the left stellate ganglion and the left second through fourth thoracic ganglia were removed through a videoscopic transthoracic approach in 8 patients with LQTS and 4 patients with catecholaminergic polymorphic ventricular tachycardia (CPVT). All patients were severely symptomatic before the ganglionectomy … |
| File Format | PDF HTM / HTML |
| DOI | 10.1161/CIRCEP.114.001589 |
| Alternate Webpage(s) | http://circep.ahajournals.org/content/circae/7/2/190.full.pdf?download=true |
| Alternate Webpage(s) | http://circep.ahajournals.org/content/circae/7/2/190.full.pdf |
| PubMed reference number | 24736420 |
| Alternate Webpage(s) | https://doi.org/10.1161/CIRCEP.114.001589 |
| Journal | Medline |
| Volume Number | 7 |
| Issue Number | 2 |
| Journal | Circulation. Arrhythmia and electrophysiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
