Loading...
Please wait, while we are loading the content...
Similar Documents
Antidiarrheal and antispasmodic activities of Adiantum capillus-veneris are predominantly mediated through ATP-dependent K+ channels activation
| Content Provider | Semantic Scholar |
|---|---|
| Author | Janbaz, Khalid Hussain Hassan, Waseem Mehmood, Hassan Gilani, Anwar H. |
| Copyright Year | 2015 |
| Abstract | The study was tempted to explore the scientific basis for the medicinal use of Adiantum capillus-veneris L. in diarrhea using the in vivo and in vitro assays. The crude extract of dried leaves of A. capillus-veneris exhibited antidiarrheal effect against castor oil-induced diarrhea in mice at 300 and 500 mg/kg, similar to the effect loperamide. It was also found safe up to administered dose of 7 g/kg in mice. In isolated rabbit jejunum, extract of A. capillus-veneris showed a concentration-dependent relaxation of spontaneous and low K + (25 mM)-induced contractions and had weak inhibitory effect on high K + (80 mM), similar to the activity pattern of cromakalim, an ATP-dependent K + channel opener. Interestingly, its inhibitory effect on spontaneous contractions was potentiated in the presence of atropine. These data demonstrates that A. capillus-veneris possesses antidiarrheal and antispasmodic properties mediated possibly through ATP-dependent K + channels activation, thus providing scientific basis to its folk use in abdominal colic and diarrhea. |
| Starting Page | 222 |
| Ending Page | 229 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.3329/bjp.v10i1.21869 |
| Volume Number | 10 |
| Alternate Webpage(s) | https://ecommons.aku.edu/cgi/viewcontent.cgi?article=1323&context=pakistan_fhs_mc_bbs |
| Alternate Webpage(s) | https://doi.org/10.3329/bjp.v10i1.21869 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
