NDLI: Carcinogenesis bioassay of chlorinated dibenzodioxins and related chemicals.

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Carcinogenesis bioassay of chlorinated dibenzodioxins and related chemicals.

Content Provider	Semantic Scholar
Author	King, Margaret E. Shefner, A. M. Bates, R. R.
Copyright Year	1973
Abstract	Chlorinated dibenzo-p-dioxins have been identified as trace contaminants of herbicides and pesticides. They may be formed as byproducts in the manufacture of chlorinated phenols and, for this reason, were implicated in outbreaks of chick edema disease (1). Fat trimmings obtained from animal hides preserved with dioxin-containing chlorophenol products and subsequently used in chicken feed contained the chick edema factor. Chloracne had been earlier observed in workers who had handled technical quality 2,4,5-trichlorophenol (2). Occasionally the condition was complicated by liver involvement and psychopathological changes. Pure 2,4,5-trichlorophenol had no effect when tested in an animal bioassay system. Tetrachlorodibenzodioxin (TCDD), which was isolated from the technical mixture, produced an effect at a concentration of 0.005%o, however (13). In addition, TDCC is the contaminant of the herbicide 2,4,5-T that produced teratogenic effects in rats (4). Subsequent work with pure TCDD has indeed shown teratogenic and embryotoxic effects in rats and mice (5-7). The fact that the chlorinated dioxins are highly toxic, teratogenic, and acnegenic does not of necessity indicate they are carcinogens
Starting Page	163
Ending Page	170
Page Count	8
File Format	PDF HTM / HTML
PubMed reference number	4752902v1
Volume Number	5
Journal	Environmental health perspectives
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/06/e4/envhper00502-0158.PMC1474975.pdf
Language	English
Access Restriction	Open
Subject Keyword	2,4,5-Trichlorophenoxyacetic Acid 2,4,5-trichlorophenol Biologic Preservation Biological Assay Chloracne Chlorophenols Contain (action) Dioxins Edema Herbicides Pesticides Phenols Platelet Glycoprotein 4, human Polychlorinated Dibenzodioxins Steroids, Chlorinated Teratogenesis Tetrachlorodibenzodioxin
Content Type	Text
Resource Type	Article

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