Loading...
Please wait, while we are loading the content...
Similar Documents
Specificity of putative partial agonist, 1-aminocyclopropanecarboxylic acid, for rat N-methyl-d-aspartate receptor subunits
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sheinin, Anton Nahum-Levy, Rinat Shavit, Sara Benveniste, Morris |
| Copyright Year | 2002 |
| Abstract | The neuroprotective compound, 1-aminocyclopropanecarboxylic acid (ACPC), has been reported to act on the N-methyl-D-aspartate (NMDA) receptors simultaneously as a glycine binding site agonist and a glutamate binding site competitive antagonist. The complex kinetics of NMDA current changes measured by a whole-cell voltage clamp in rat hippocampal neurons resulting from application and removal of 1 mM ACPC in the continual presence of 15 microM NMDA confirm this hypothesis. Two-electrode voltage clamp on Xenopus oocytes expressing NR1-1a and either NR2A, NR2B or NR2C subunits yielded biphasic ACPC dose response curves with 15 microM NMDA. NR1-1a/NR2B and NR1-1a/NR2C subunit combinations yielded overlapping dose response curves with a maximal efficacy of approximately 80%; the maximal efficacy of ACPC for the NR1-1a/NR2A subunit combination was significantly lower at approximately 60%. |
| Starting Page | 77 |
| Ending Page | 80 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0304-3940(01)02430-2 |
| PubMed reference number | 11755244 |
| Journal | Medline |
| Volume Number | 317 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304394001024302 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304394001024302?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0304-3940%2801%2902430-2 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
