NDLI: Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer.

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Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer.

Content Provider	Semantic Scholar
Author	Zhang, Xianglan Zheng, Zhenlong Yingji, Shen Kim, Hye Yeon Jin, Renshun Renshu, Li Lee, Doo Young Roh, Mi Ryung Yang, Sanghwa
Copyright Year	2014
Abstract	Glutathione peroxidase 3 (GPX3) is a member of the glutathione peroxidase family of selenoproteins and is one of the key defensive enzymes against oxidative damages to host cells. Downregulation of GPX3 due to its promoter hypermethylation has been documented in several different types of cancer, indicating that GPX3 functions as a possible tumor suppressor. In the present study, we showed that GPX3 is also significantly downregulated in cervical cancer tissues compared to normal cervical tissues by qRT-PCR analyses and immunohistostainings. GPX3 expression was significantly related to lymph node metastasis and prognosis in cervical cancer patients. Treatment of cervical cancer cells with 5-aza-2'-deoxycytidine restored the expression of GPX3 and methylation-specific PCR (MSP) confirmed the CpG methylation of the GPX3 gene. Our results indicate that promoter methylation is one of the major causes of GPX3 downregulation in cervical cancer and GPX3 could serve as a predictive biomarker for lymph node metastasis and prognosis of cervical cancer.
Starting Page	54
Ending Page	88
Page Count	35
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.spandidos-publications.com/or/31/6/2587/download
PubMed reference number	24788695v1
Alternate Webpage(s)	https://doi.org/10.3892/or.2014.3152
DOI	10.3892/or.2014.3152
Journal	Oncology reports
Volume Number	31
Issue Number	6
Language	English
Access Restriction	Open
Subject Keyword	Anatomic Node Biological Markers Body tissue Cervix carcinoma Document completion status - Documented Down-Regulation Forecast of outcome GPX3 gene Hypermethylation Lymphadenopathy Methylation Neck Neoplasms Patients Selenoproteins decitabine lymph node metastases lymph nodes pediatric intracranial germ cell brain tumor
Content Type	Text
Resource Type	Article

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