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Plasma β amyloid and impaired CO2-induced cerebral vasomotor reactivity
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dijk, Ewoud J. Van Prins, Niels Daniël Hofman, Albert Duijn, Cornelia M. Van Breteler, Monique M. B. |
| Copyright Year | 2007 |
| Abstract | Abstract Amyloid β (Aβ) may disturb cerebral autoregulation by damaging the wall of small cerebral blood vessels and by direct negative vasoactive properties. We assessed whether previous and concurrent plasma Aβ 1–40 and Aβ 1–42 levels were associated with an impaired CO 2 -induced cerebral vasomotor response. In the longitudinal population-based Rotterdam Study we measured plasma Aβ levels and cerebral vasomotor reactivity to hypercapnia with transcranial Doppler ultrasonography (TCD) in 441 people, aged 60–90 years. We performed age and sex adjusted logistic regression analysis. Plasma Aβ levels assessed on average 6.5-year before TCD were linearly associated with an impaired CO 2 -induced cerebral vasomotor response (odds ratio 1.48 (95%CI 1.19;1.84) per standard deviation increase in Aβ 1–40 , and 1.36 (95%CI 1.09;1.70) per standard deviation increase in Aβ 1–42 ). Such an association was not present for Aβ assessed concurrently with the TCD measurement. Persons whose plasma Aβ 1–40 levels had decreased in the 6.5-year period preceding TCD measurements were more likely to have an impaired CO 2 -induced vasomotor reactivity. Overall our observations are most compatible with plasma Aβ levels representing vascular Aβ deposits years later resulting in impaired CO 2 -induced vasomotor reactivity. |
| Starting Page | 707 |
| Ending Page | 712 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neurobiolaging.2006.03.011 |
| Volume Number | 28 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0197458006001102 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0197458006001102?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neurobiolaging.2006.03.011 |
| Journal | Neurobiology of Aging |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
