NDLI: In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.

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In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.

Content Provider	Semantic Scholar
Author	Griguoli, Marilena Cellot, Giada Cherubini, Enrico
Copyright Year	2013
Abstract	In the hippocampus, at excitatory synapses between principal cell and oriens/alveus (O/A) interneurons, a particular form of NMDA-independent long-term synaptic plasticity (LTP) has been described (Lamsa et al., 2007). This type of LTP occurs when presynaptic activation coincides with postsynaptic hyperpolarization. For this reason it has been named "anti-Hebbian" to distinguish from the classical Hebbian type of associative learning where presynaptic glutamate release coincides with postsynaptic depolarization. The different voltage dependency of LTP induction is thought to be mediated by calcium-permeable (CP) AMPA receptors that, due to polyamine-mediated rectification, favor calcium entry at hyperpolarized potentials. Here, we report that the induction of this form of LTP needs CP-α7 nicotinic acetylcholine receptors (nAChRs) that, like CP-AMPARs, exhibit a strong inward rectification because of polyamine block at depolarizing potentials. We found that high-frequency stimulation of afferent fibers elicits synaptic currents mediated by α7 nAChRs. Hence, LTP was prevented by α7 nAChR antagonists dihydro-β-erythroidine and methyllycaconitine (MLA) and was absent in α7(-/-) mice. In addition, in agreement with previous observations (Le Duigou and Kullmann, 2011), in a minority of O/A interneurons in MLA-treated hippocampal slices from WT animals and α7(-/-) mice, a form of LTP probably dependent on the activation of group I metabotropic glutamate receptors was observed. These data indicate that, in O/A interneurons, anti-Hebbian LTP critically depends on cholinergic signaling via α7 nAChR. This may influence network oscillations and information processing.
Starting Page	394
Ending Page	402
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/33/3/1044.full.pdf
PubMed reference number	23325242v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.1070-12.2013
DOI	10.1523/jneurosci.1070-12.2013
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	33
Issue Number	3
Language	English
Access Restriction	Open
Subject Keyword	AMPA Receptors Acetylcholine Calcium Cholinergic Receptors Glutamate Receptor Glutamic Acid Interneurons Learning Disorders Long-Term Potentiation N-Methylaspartate Name Neuronal Plasticity Nicotinic Receptors Receptors, Metabotropic Glutamate Receptors, Serotonin, 5-HT2 Structure of alveus of hippocampus Synapses Tissue fiber chemosensitization/potentiation emotional dependency methyllycaconitine voltage
Content Type	Text
Resource Type	Article

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