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Controlling Fluid Diffusion and Release through Mixed-Molecular-Weight Poly(ethylene) Glycol Diacrylate (PEGDA) Hydrogels
| Content Provider | Semantic Scholar |
|---|---|
| Author | Donnell, Kieran O’ Boyd, Adrian R. Meenan, Brian |
| Copyright Year | 2019 |
| Abstract | Due to their inherent ability to swell in the presence of aqueous solutions, hydrogels offer a means for the delivery of therapeutic agents in a range of applications. In the context of designing functional tissue-engineering scaffolds, their role in providing for the diffusion of nutrients to cells is of specific interest. In particular, the facility to provide such nutrients over a prolonged period within the core of a 3D scaffold is a critical consideration for the prevention of cell death and associated tissue-scaffold failure. The work reported here seeks to address this issue via fabrication of hybrid 3D scaffolds with a component fabricated from mixed-molecular-weight hydrogel formulations capable of storing and releasing nutrient solutions over a predetermined time period. To this end, poly(ethylene) glycol diacrylate hydrogel blends comprising mixtures of PEGDA-575 Mw and PEGDA-2000 Mw were prepared via UV polymerization. The effects of addition of the higher-molecular-weight component and the associated photoinitiator concentration on mesh size and corresponding fluid permeability have been investigated by diffusion and release measurements using a Theophylline as an aqueous nutrient model solution. Fluid permeability across the hydrogel films has also been determined using a Rhodamine B solution and associated fluorescence measurements. The results indicate that addition of PEGDA-2000 Mw to PEGDA-575 Mw coupled with the use of a specific photoinitiator concentration provides a means to change mesh size in a hydrogel network while still retaining an overall microporous material structure. The range of mesh sizes created and their distribution in a 3D construct provides for the conditions required for a more prolonged nutrient release profile for tissue-engineering applications. |
| File Format | PDF HTM / HTML |
| DOI | 10.3390/ma12203381 |
| PubMed reference number | 31623186 |
| Journal | Medline |
| Volume Number | 12 |
| Journal | Materials |
| Alternate Webpage(s) | https://res.mdpi.com/d_attachment/materials/materials-12-03381/article_deploy/materials-12-03381.pdf |
| Alternate Webpage(s) | https://doi.org/10.3390/ma12203381 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
