Synaptic contacts between nerve terminals originating from the ventrolateral medullary catecholaminergic area and median preoptic neurons projecting to the paraventricular hypothalamic nucleus

Content Provider	Semantic Scholar
Author	Kawano, Hitoshi Masuko, Sadahiko
Copyright Year	1999
Abstract	A significant role of catecholaminergic projection to the median preoptic nucleus (POMe) which activates vasopressin-producing cells of the paraventricular hypothalamic nucleus (PVN) has been suggested. We investigated the existence of the synaptic contacts between catecholaminergic fibers from the ventrolateral medulla and the POMe neurons projecting to the PVN. Rats received a retrograde tracer in the PVN and subsequently an anterograde tracer into the catecholaminergic area of the ventrolateral medulla at the level of the area postrema. In the POMe, anterogradely labeled nerve terminals were found to make axo-somatic and axo-dendritic synaptic contacts onto retrogradely labeled neurons. Additional studies in which a retrograde tracer was injected into the POMe revealed that almost all retrogradely labeled neurons in the ventrolateral medulla at the level of the area postrema were immunoreactive to tyrosine hydroxylase, suggesting that projection to the POMe from the ventrolateral medulla is largely limited to catecholamine neurons. These results provide, for the first time, direct evidence that catecholaminergic inputs from the ventrolateral medulla affect POMe neurons projecting to the PVN by way of direct synaptic contact.
Starting Page	110
Ending Page	116
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/S0006-8993(98)01233-5
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006899398012335
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006899398012335?dgcid=api_sd_search-api-endpoint
PubMed reference number	9889341
Alternate Webpage(s)	https://doi.org/10.1016/S0006-8993%2898%2901233-5
Journal	Medline
Volume Number	817
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article