The Relationship among N-Terminal Pro-B-Type Natriuretic Peptide, High-Sensitivity C-Reactive Protein and Infarct Size in Patients with Acute ST-Elevation Myocardial Infarction

Content Provider	Semantic Scholar
Author	Ahn, Youngkeun Seon, Hyun Ju Park, Keun Ho Yoon, Hyun Ju Yoon, Nam Sik Joon, Young Park, Hyung Wook Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun
Copyright Year	2015
Abstract	BACKGROUND AND OBJECTIVES We sought to investigate the relationship between levels of high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the infarct size and left ventricular (LV) volume after acute myocardial infarction (MI). SUBJECTS AND METHODS Eighty-six patients with acute ST-elevation MI underwent delayed enhancement multidetector computed tomography immediately after they underwent percutaneous coronary intervention to determine the infarct size. LV function and remodeling were assessed by echocardiography. Hs-CRP and NT-proBNP were measured at admission, 24 hours and two months later. RESULTS Both hs-CRP and NT-proBNP at 24 hours showed a positive correlation with infarct size and a negative correlation with LV ejection fraction at the baseline and two months later. NT-proBNP at two months correlated with infarct size, LV ejection fraction, and LV end diastolic and systolic volume indices at two months. In patients with high NT-proBNP levels at 24 hours and two months, infarct size was larger and LV ejection fraction was lower. NT-proBNP was higher in patients who developed LV remodeling at two months: 929 pg/mL vs. 134 pg/mL, p=0.002. In contrast, hs-CRP at two months showed no relationship to infarct size, LV function, or LV volumes at two months. CONCLUSION Elevated hs-CRP level 24 hours after the onset of acute MI is associated with infarct size and LV dysfunction, whereas elevated levels of NT-proBNP 24 hours and two months after the onset of acute MI are both correlated with infarct size, LV dysfunction, and LV remodeling.
Starting Page	285
Ending Page	293
Page Count	9
File Format	PDF HTM / HTML
DOI	10.4070/kcj.2015.45.4.285
PubMed reference number	26240582
Journal	Medline
Volume Number	45
Alternate Webpage(s)	https://synapse.koreamed.org/Synapse/Data/PDFData/0054KCJ/kcj-45-285.pdf
Alternate Webpage(s)	https://doi.org/10.4070/kcj.2015.45.4.285
Journal	Korean circulation journal
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article