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Inverted U-Shaped Relation Between the Risk of Sudden Cardiac Death and Maximal Left Ventricular Wall Thickness in Hypertrophic Cardiomyopathy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | O'Mahony, Constantinos Jichi, Fatima Monserrat, Lorenzo Ortiz-Genga, Martín F. Anastasakis, Aristides Rapezzi, Claudio Biagini, Elena Gimeno, Juan R. Limongelli, G. Gianna Giovamma McKenna, William J. Omar, Rumana Z. Elliott, Perry M. |
| Copyright Year | 2016 |
| Abstract | BACKGROUND Hypertrophic cardiomyopathy is associated with sudden cardiac death (SCD). Some studies have shown an association between risk of sudden death and left ventricular maximal wall thickness (MWT), but there are few data in patients with extreme hypertrophy. The aim of this study was to determine the relation between MWT and the risk of SCD. METHODS AND RESULTS This is a multicenter, retrospective, longitudinal cohort study of 3673 adult (≥16 years) patients, previously used to develop and validate a risk prediction model for SCD (HCM Risk-SCD [hypertrophic cardiomyopathy risk-SCD]). There was an inverted U-shaped relation between MWT and the estimated 5-year risk of SCD. In patients with MWT≥35 mm (n=47; mean age, 33 years; 81% men), there was a single SCD end point (annual rate, 0.2%; 95% confidence interval, 0.03-1.60) and 3 additional cardiovascular events during a median follow-up of 9.5 years. Compared with patients with MWT≤14 mm, those with MWT≥35 mm did not have a higher risk for SCD (hazard ratio, 0.22; 95% confidence interval, 0.03-1.65), cardiovascular death (hazard ratio, 0.66; 95% confidence interval, 0.26-1.67), or all-cause mortality (hazard ratio, 0.73; 95% confidence interval, 0.32-1.69). CONCLUSIONS The risk of SCD has a complex, nonlinear relationship to MWT. The pathophysiological mechanisms behind this observation require further study but implantable cardioverter defibrillator implantation should not be guided solely on the severity of left ventricular hypertrophy. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circep.ahajournals.org/content/circae/9/6/e003818.full.pdf?download=true |
| PubMed reference number | 27217341v1 |
| Alternate Webpage(s) | https://doi.org/10.1161/CIRCEP.115.003818 |
| DOI | 10.1161/circep.115.003818 |
| Journal | Circulation. Arrhythmia and electrophysiology |
| Volume Number | 9 |
| Issue Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cardiomyopathies Cessation of life Confidence Intervals Defibrillators Hazard Ratio Heart Ventricle Hypertrophic Cardiomyopathy Hypertrophic disorder of skin, unspecified Implants Left Ventricular Hypertrophy Patients Sudden Cardiac Death Sudden death Tachycardia, Ventricular defibrillator/cardioverters |
| Content Type | Text |
| Resource Type | Article |
