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Cigarettes and ADMA: the smoke hasn't cleared yet.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kielstein, Jan T. Peter, Christoph Adams, M. Christopher |
| Copyright Year | 2006 |
| Abstract | To the Editor: The recent study by Zhang et al1 indicates that exposure to cigarette smoke extracts (CSE) increases the concentration of the endogenous NO synthase inhibitor asymmetrical dimethyl-arginine (ADMA) in human endothelial cells in vitro. They provide evidence that CSE decreases L-arginine uptake in the cells, in part because of a decreased expression of the type 1 cationic amino acid transporter. Moreover, after incubation with CSE, the intracellular ADMA concentration was significantly higher, and the L-arginine concentrations significantly lower, than in the control cells. This increase in intracellular ADMA, which also leads to a decreased … |
| File Format | PDF HTM / HTML |
| DOI | 10.1161/01.HYP.0000240013.09503.0a |
| PubMed reference number | 16923996 |
| Journal | Medline |
| Volume Number | 48 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/48/4/E20.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1161/01.HYP.0000240013.09503.0a |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
